Centro ricerche Imaging Cardiovascolare Multimodale Integrato

DIRETTORE

Prof. Luigi Badano

COORDINATORI

ÉQUIPE

ATTIVITÀ DI RICERCA

L’attività del Centro di Ricerca su Imaging Cardiovascolare Multimodale Integrato è principalmente rivolta allo studio del valore diagnostico e prognostico aggiunto delle nuove tecnologie di imaging cardiovascolare non invasivo, valore diagnostico e prognostico del cateterismo destro a riposo e da sforzo nella diagnostica delle dispnee, applicazioni dell’intelligenza artificiale all’imaging cardiovascolare, utilizzo di tecniche di realtà artificiale e realtà estesa per aumentare la capacità diagnostica dell’imaging cardiovascolare noninvasivo, valutazione storia naturale e markers prognostici nei pazienti con cardiopatie valvolari, ricerca dei predittori di morte cardiaca improvvisa in pazienti con cardiopatia strutturale, valutazione della funzione ventricolare destra, valutazione e significato prognostico della funzione degli atri.

Il Centro di Ricerca su Imaging Cardiovascolare Multimodale funge inoltre da core-lab ecocardiografico per studi clinici organizzati da Auxologico o commissionati dall’industria e da altre Istituzioni scientifiche.

Il Centro di Ricerca su Imaging Cardiovascolare Multimodale collabora attivamente con l’industria ed ha formali contratti di ricerca con GE Healthcare (Horten, Norvegia), Philips Medical Systems (Andover, MA, USA), EsaOte SpA (Genova Italia), TomTec Imaging Systems (Unterschleissen, Germania).

Il Centro di Ricerca su Imaging Cardiovascolare Multimodale ha collaborazioni di ricerca con il National Institute of Health (USA), Québec Heart and Lung Institute, Laval University (Québec City, Canada), Università degli Studi di Verona, Verona (Italy); Leiden University Medical Centre, LUMC, Leiden (Nederland); Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul (South Korea); Semmelweis University, Heart and Vascular Center, Budapest (Hungary): Argus Cognitive, Inc., Lebanon, (NH, USA); Heart & Vascular Center, University of Chicago Medicine (IL, USA); LE CENTRE HOSPITALIER UNIVERSITAIRE DE RENNES, Hôpital Pontchaillou,RENNES (Cedex 9, France);  Medizinische Klinik und Poliklinik I, Ludwig-Maximilians Universität (LMU), München (Germany); University Hospital Ramon y Cajal, Madrid (Spain)

Il Centro di Ricerca su Imaging Cardiovascolare Multimodale si avvale del contributo di 1 dottorandi di ricerca, 1 tecnico di ecocardiografia, 2 bioingegneri e di diversi ricercatori che provengono da altre università italiane e straniere (Romania, Giappone).

MALATTIE OGGETTO DI RICERCA

  • Cardiopatia ischemica;
  • Insufficienza tricuspidale;
  • Insufficienza mitralica;
  • Stenosi aortica;
  • Fibrillazione atriale;
  • Cardiomiopatia ipertrofica;
  • Amiloidosi cardiaca;
  • Scompenso cardiaco a frazione d’eiezione conservata;
  • Cuore d’atleta;
  • Cardiopatia ipertensiva;
  • Ipertensione polmonare.

RISULTATI DI PARTICOLARE IMPORTANZA RAGGIUNTI 

Brevetti

Brevetto (categoria innovazione ed alto contenuto tecnologico) di un software per il supporto all'operatore per acquisizione di immagini di risonanza magnetica cardiaca di alta qualità.

Bandi di ricerca competitivi

  1. Bando Ricerca Finalizzata 2021 (fondi 2020-2021) Progetto# RF-2021-12374122.di tipo …Theory-enhancing dal titolo “In-depth characterization of atriogenic secondary tricuspid regurgitation due to atrial fibrillation. Prevalence, mechanisms, advanced quantification of regurgitation severity, and relative impact of sinus rhythm restoration on the 3D remodeling of right heart chambers and tricuspid valve apparatus”.
    https://www.salute.gov.it/portale/ministro/p4_10_1_1_atti_1_1.jsp?lingua=italiano&id=283
  2. Bando PNRR 2022. Progetto codice .PNRR-MAD-2022-12375700.nella  sezione Malattie Croniche non Trasmissibili (MCnT) ad alto impatto sui sistemi sanitari e socio-assistenziali dal titolo “ Use of intepREtable artificial intelligence techniqueS for a PErsonalized risk prediCTion of sudden cardiac death in patients with ischemic and non-ischemic left ventricular dysfunction.The RESPECT project”.
    https://www.salute.gov.it/portale/ministro/p4_10_1_1_atti_1_1.jsp?lingua=italiano&id=283

Pubblicazioni (ultimi 2 anni)

2024

  1.  Tomaselli M, Badano LP, Oliverio G, Curti E, Pece C, Springhetti P, Milazzo S, Clement A, Penso M, Gavazzoni M, Hădăreanu DR, Mihaila SB, Pugliesi GM, Delcea C, Muraru D. Clinical Impact of the Volumetric Quantification of Ventricular Secondary Mitral Regurgitation by Three-dimensional Echocardiography. J Am Soc Echocardiogr. 2024 Jan 18: S0894-7317(24)00007-5. doi: 10.1016/j.echo.2024.01.004. Epub ahead of print. PMID: 38244817
  2.  Tomaselli M, Radu DN, Badano LP, Perelli FP, Heilbron F, Cascella A, Gavazzoni M, Hădăreanu DR, Mihaila S, Oliverio G, Penso M, Caravita S, Baratto C, Fisicaro S, Parati G, Muraru D. Right Atrial Remodeling and Outcome in Patients with Secondary Tricuspid Regurgitation. J Am Soc Echocardiogr. 2024 Jan 11:S0894-7317(24)00004-X. doi: 10.1016/j.echo.2024.01.003. Epub ahead of print. PMID: 38218553.
  3.  Badano LP, Muraru D. Make Right Heart Remodeling in Secondary Tricuspid Regurgitation as Simple as Possible, But Not Simpler. JACC Cardiovasc Imaging. 2024 Mar 11:S1936-878X(24)00058-5. doi: 10.1016/j.jcmg.2024.02.002. Epub ahead of print. PMID: 38520426.
  4.  Muraru D, Badano LP, Hahn RT, Lang RM, Delgado V, Wunderlich NC, Donal E, Taramasso M, Duncan A, Lurz P, De Potter T, Zamorano Gómez JL, Bax JJ, von Bardeleben RS, Enriquez-Sarano M, Maisano F, Praz F, Sitges M. Atrial secondary tricuspid regurgitation: pathophysiology, definition, diagnosis, and treatment. Eur Heart J. 2024 Mar 14;45(11):895-911. doi: 10.1093/eurheartj/ehae088. PMID: 38441886.
  5.  Muraru D, Badano LP. Leaflet Coaptation Gaps in Severe Tricuspid Regurgitation: Unraveling the Morphological Challenges in the Tricuspid Transcatheter Edge-to-Edge Repair Landscape. J Am Soc Echocardiogr. 2024; 37:405-7. doi: 10.1016/j.echo.2024.01.011. Epub ahead of print. PMID: 38309592.
  6.  Badano LP, Benfari G, Muraru D. The Conundrum of the Reference Values of Left Atrial Size and Function. Eur Heart J Cardiovasc Imaging. 2024 Feb 3:jeae039. doi: 10.1093/ehjci/jeae039. Epub ahead of print. PMID: 38309953
  7.  Springhetti P, Tomaselli M, Benfari G, Milazzo S, Ciceri L, Penso M, Pilan M, Clement A, Rota A, Del Sole PA, Nistri S, Muraru D, Ribichini F, Badano L. Peak Atrial Longitudinal Strain and Risk Stratification in Moderate and Severe Aortic Stenosis. Eur Heart J Cardiovasc Imaging. 2024 Feb 6:jeae040. doi: 10.1093/ehjci/jeae040. Epub ahead of print. PMID: 38319610.
  8.  Bertero E, Chiti C, Schiavo MA, Tini G, Costa P, Todiere G, Mabritto B, Dei LL, Giannattasio A, Mariani D, Lofiego C, Santolamazza C, Monda E, Quarta G, Barbisan D, Mandoli GE, Mapelli M, Sguazzotti M, Negri F, De Vecchi S, Ciabatti M, Tomasoni D, Mazzanti A, Marzo F, de Gregorio C, Raineri C, Vianello PF, Marchi A, Biagioni G, Insinna E, Parisi V, Ditaranto R, Barison A, Giammarresi A, De Ferrari GM, Priori S, Metra M, Pieroni M, Patti G, Imazio M, Perugini E, Agostoni P, Cameli M, Merlo M, Sinagra G, Senni M, Limongelli G, Ammirati E, Vagnarelli F, Crotti L, Badano L, Calore C, Gabrielli D, Re F, Musumeci G, Emdin M, Barbato E, Musumeci B, Autore C, Biagini E, Porto I, Olivotto I, Canepa M. Real-world candidacy to mavacamten in a contemporary hypertrophic obstructive cardiomyopathy population. Eur J Heart Fail. 2024 Jan;26(1):59-64. doi: 10.1002/ejhf.3120. Epub 2024 Jan 2. PMID: 38131253.
  9.  Adamo M, Chioncel O, Pagnesi M, Bayes-Genis A, Abdelhamid M, Anker SD, Antohi EL, Badano L, Ben Gal T, Böhm M, Delgado V, Dreyfus J, Faletra FF, Farmakis D, Filippatos G, Grapsa J, Gustafsson F, Hausleiter J, Jaarsma T, Karam N, Lund L, Lurz P, Maisano F, Moura B, Mullens W, Praz F, Sannino A, Savarese G, Tocchetti CG, van Empel VPM, von Bardeleben RS, Yilmaz MB, Zamorano JL, Ponikowski P, Barbato E, Rosano GMC, Metra M. Epidemiology, pathophysiology, diagnosis and management of chronic right-sided heart failure and tricuspid regurgitation. A clinical consensus statement of the Heart Failure Association (HFA) and the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC. Eur J Heart Fail. 2024 Jan;26(1):18-33. doi: 10.1002/ejhf.3106. Epub 2024 Jan 14. PMID: 38131233.
  10.  Springhetti P, Benfari G, Nistri S, Jannello EMS, Mandoli GE, Badano L, Ribichini FL, Muraru D. Diagnostic Contexts of Echocardiographic Nonapical Window. JACC Case Rep. 2024 Mar 11;29(9):102287. doi: 10.1016/j.jaccas.2024.102287. PMID: 38500538; PMCID: 10945174
  11.  Russo G, Hahn RT, Alessandrini H, Andreas M, Badano LP, Braun D, Connelly KA, Denti P, Estevez-Loureiro R, Fam N, Gavazzoni M, Hausleiter J, Himbert D, Kalbacher D, Latib A, Lubos E, Ludwig S, Lurz P, Monivas V, Nickenig G, Pedicino D, Pedrazzini G, Pozzoli A, Praz F, Rodes-Cabau J, Rommel KP, Schofer J, Sievert H, Tang G, Thiele H, Unterhuber M, von Bardeleben RS, Webb J, Windecker S, Leon M, Maisano F, Taramasso M. Effects of tricuspid transcatheter edge-to-edge repair on tricuspid annulus diameter - Data from the TriValve registry. Int J Cardiol. 2024 Mar 2:131934. doi: 10.1016/j.ijcard.2024.131934. Epub ahead of print. PMID: 38437953
  12.  Pagura L, Porcari A, Cameli M, Biagini E, Canepa M, Crotti L, Imazio M, Forleo C, Pavasini R, Limongelli G, Perlini S, Metra M, Boriani G, Emdin M, Sinagra G, Merlo M; ACTIVE study group. ECG/echo indexes in the diagnostic approach to amyloid cardiomyopathy: A head-to-head comparison from the AC-TIVE study. Eur J Intern Med. 2024; 122: 68-77 doi: 10.1016/j.ejim.2023.09.026. Epub ahead of print. PMID: 37858441
  13.  Tomaselli M, Badano LP, Muraru D. Right atrial function, a mostly ignored but very valuable parameter in patients with secondary tricuspid regurgitation. Heart. 2024 Feb 23;110(6):389-390. doi: 10.1136/heartjnl-2023-323426. PMID: 37932022
  14.  Dreyfus J, Galloo X, Taramasso M, Heitzinger G, Benfari G, Kresoja KP, Juarez-Casso F, Omran H, Bohbot Y, Iliadis C, Russo G, Topilsky Y, Weber M, Nombela-Franco L, Sala A, Eixerés-Esteve A, Iung B, Obadia JF, Estevez Loureiro R, Riant E, Donal E, Hausleiter J, Badano L, Le Tourneau T, Coisne A, Modine T, Latib A, Praz F, Windecker S, Zamorano JL, von Bardeleben RS, Tang GHL, Hahn R, Webb J, Muraru D, Nejjari M, Chan V, De Bonis M, Carnero-Alcazar M, Nickenig G, Pfister R, Tribouilloy C, Rudolph V, Crestanello J, Lurz P, Bartko P, Maisano F, Bax J, Enriquez-Sarano M, Messika-Zeitoun D; TRIGISTRY investigators. TRI-SCORE and benefit of intervention in patients with severe tricuspid regurgitation. Eur Heart J. 2024 Feb 21;45(8):586-597. doi: 10.1093/eurheartj/ehad585. PMID: 37624856
  15.  Andreas M, Burri H, Praz F, Soliman O, Badano L, Barreiro M, Cavalcante JL, de Potter T, Doenst T, Friedrichs K, Hausleiter J, Karam N, Kodali S, Latib A, Marijon E, Mittal S, Nickenig G, Rinaldi A, Rudzinski P, Russo M, Starck C, von Bardeleben RS, Wunderlich N, Zamorano JL, Hahn RT, Maisano F, Leclercq C. Tricuspid valve disease and cardiac implantable electronic devices. Eur Heart J. 2024 Feb 1;45(5):346-365. doi: 10.1093/eurheartj/ehad783. Erratum in: Eur Heart J. 2024 Mar 29;: PMID: 38096587; PMCID: PMC10834167
  16.  Adamo M, Russo G, Pagnesi M, Edoardo P, Alessandrini H, Martin, A, Badano LP, Braun D, Connelly KA, Denti P, Estevez-Luoreiro R, Fam N, Gavazzoni M, hahn RT, Harr C, Hausleiter J, Himbert D, Kalbacher D, Ho E, Latib A, Lubos E, Ludwig S, Lupi L, Lurz P, Monivas V, Nickenig G, Pedicino D, Pedrazzini G, Pozzoli A, Marafon DP, Pastprino R, Praz F, Rodes-Cabau J, Besler C, Schober AR, Schofer J, Scottoi A, Piayda K, Sievert H, Tang GHL, Sticchi A, Messika-Zeitoun D, Thiele H, Schlotter F, von Bardeleben RS, Webb J, Dreyfus J, Windecker S, Leon M, Maisano F, Metra M, Taramasso M. Prediction of mortality and heart failure hospitalization after transcatheter valve interventions. Validation of TRISCORE. JACC Cardiovasc Interventions 2024; 17: 859-70
  17.  Fisicaro S, Clement A, Tomaselli M, Penso M, Rota A, Menna A, Badano LP, Muraru D. Timing and Patients' Position During Cuff Blood Pressure Measurement Affect Myocardial Work Parameters Measured by Echocardiography. J Am Soc Echocardiogr. 2024 Apr 7:S0894-7317(24)00166-4. doi: 10.1016/j.echo.2024.03.018. Epub ahead of print. PMID: 38593889
  18.  Dreyfus J, Taramasso M, Kresoja KP, Omran H, Iliadis C, Russo G, Weber M, Nombela-Franco L, Estevez Loureiro R, Hausleiter J, Latib A, Stolz L, Praz F, Windecker S, Zamorano JL, von Bardeleben RS, Tang GHL, Hahn R, Lubos E, Webb J, Schofer J, Fam N, Lauten A, Pedrazzini G, Rodés-Cabau J, Nejjari M, Badano L, Alessandrini H, Himbert D, Sievert H, Piayda K, Donal E, Modine T, Nickenig G, Pfister R, Rudolph V, Bernick J, Wells GA, Bax J, Lurz P, Enriquez-Sarano M, Maisano F, Messika-Zeitoun D; TRIGISTRY Investigators. Prognostic Implications of Residual Tricuspid Regurgitation Grading After Transcatheter Tricuspid Valve Repair. JACC Cardiovasc Interv. 2024 May 7:S1936-8798(24)00692-7. doi: 10.1016/j.jcin.2024.04.023
  19.  Tolvaj M, Kovács A, Radu N, Cascella A, Muraru D, Lakatos B, Fábián A, Tokodi M, Tomaselli M, Gavazzoni M, Perelli F, Merkely B, Badano LP, Surkova E. Significant Disagreement Between Conventional Parameters and 3D Echocardiography-Derived Ejection Fraction in the Detection of Right Ventricular Systolic Dysfunction and Its Association With Outcomes. J Am Soc Echocardiogr. 2024 Apr 17:S0894-7317(24)00173-1. doi: 10.1016/j.echo.2024.04.005.
  20. Dreyfus J, Juarez-Casso F, Sala A, Carnero-Alcazar M, Eixerés-Esteve A, Bohbot Y, Bazire B, Flagiello M, Riant E, Mbaki Y, Tomasi J, Senage T, Rahmouni El Idrissi K, Coisne A, Eyharts D, Doguet F, Viau F, Eggenspieler F, Heuts S, Sardari Nia P, Heitzinger G, Galloo X, Ajmone Marsan N, Benfari G, Badano L, Muraru D, Maisano F, Topilsky Y, Michelena H, Enriquez-Sarano M, Bax J, Bartko P, Selton-Suty C, Habib G, Lavie-Badie Y, Modine T, Chan V, Le Tourneau T, Donal E, Lim P, Radu C, Bernick J, Wells GA, Tribouilloy C, Iung B, Obadia JF, De Bonis M, Crestanello J, Messika-Zeitoun D; TRIGISTRY investigators. Benefit of isolated surgical valve repair or replacement for functional tricuspid regurgitation and long-term outcomes stratified by the TRI-SCORE. Eur Heart J. 2024 Aug 30:ehae578. doi: 10.1093/eurheartj/ehae578. Epub ahead of print. PMID: 39212387.
  21.  Papadopoulos K, Badano LP, Vannan MA, Cameli M, Palmisano A, Ancona F, Esposito A. Editorial: Advances in heart valve imaging. Front Cardiovasc Med. 2024 Jul 11;11:1450661. doi: 10.3389/fcvm.2024.1450661. PMID: 39055662; PMCID: PMC11269213.
  22.  Gavazzoni M, Badano LP, Pugliesi GM, Penso M, Hădăreanu DR, Ciampi P, Fisicaro S, Oliverio G, Heilbron F, Tomaselli M, Muraru D. Assessing Right Atrial Size in Patients with Tricuspid Regurgitation: Importance of the Right Ventricular-Focused View. Eur Heart J Cardiovasc Imaging. 2024 Nov 27;25(12):1743-1750. doi: 10.1093/ehjci/jeae186. PMID: 39052930; PMCID: PMC11601883.
  23. Badano LP, Tomaselli M, Muraru D, Galloo X, Li CHP, Ajmone Marsan N. Advances in the Assessment of Patients With Tricuspid Regurgitation: A State-of-the-Art Review on the Echocardiographic Evaluation Before and After Tricuspid Valve Interventions. J Am Soc Echocardiogr. 2024 Jul 17:S0894-7317(24)00356-0. doi: 10.1016/j.echo.2024.07.008. Epub ahead of print. PMID: 39029717.
  24. Muraru D, Badano LP. Impact of new-onset atrial fibrillation on the incidence of tricuspid regurgitation: a call to attention. Eur Heart J. 2024 Aug 16;45(31):2891-2893. doi: 10.1093/eurheartj/ehae382. PMID: 38973019
  1. Akyea RK, Figliozzi S, Lopes PM, Bauer KB, Moura-Ferreira S, Tondi L, Mushtaq S, Censi S, Pavon AG, Bassi I, Galian-Gay L, Teske AJ, Biondi F, Filomena D, Stylianidis V, Torlasco C, Muraru D, Monney P, Quattrocchi G, Maestrini V, Agati L, Monti L, Pedrotti P, Vandenberk B, Squeri A, Lombardi M, Ferreira AM, Schwitter J, Aquaro GD, Pontone G, Chiribiri A, Rodríguez Palomares JF, Yilmaz A, Andreini D, Florian AR, Francone M, Leiner T, Abecasis J, Badano LP, Bogaert J, Georgiopoulos G, Masci PG. Arrhythmic Mitral Valve Prolapse Phenotype: An Unsupervised Machine Learning Analysis Using a Multicenter Cardiac MRI Registry. Radiol Cardiothorac Imaging. 2024 Jun;6(3):e230247. doi: 10.1148/ryct.230247. PMID: 38900026 
  2. Badano LP, Tomaselli M, Gavazzoni M, Clement A, Muraru D. Management of Isolated Tricuspid Regurgitation: 2 Sides of the Same Coin. JACC Cardiovasc Interv. 2024 Jun 10;17(11):1408. doi: 10.1016/j.jcin.2024.04.033. PMID: 38866464 
  3. Tomaselli M, Penso M, Badano LP, Clement A, Radi N, Heilbronn F, Gavazzoni M, Hadareanu DR, Oliverio G, Fisicaro S, Springhetti P, Pece C, Delcea C, Muraru D. Association with Outcomes of Correcting the PISA Method to Quantitate Secondary Tricuspid Regurgitation. J Am Soc Echocardiogr. 2024 Nov 5:S0894-7317(24)00561-3. doi: 10.1016/j.echo.2024.10.015. Epub ahead of print. PMID: 39510358
  4. Fudim M, Kittipibul V, Swavely A, Gray A, Mikitka J, Young E, Dobbin O, Radzom M, Fee J, Molinger J, Patterson B, Battista Perego G, Badano LP, Parati G, Vachiéry JL, Senni M, Lanzarone E, Previdi F, Paleari S, Baratto C, Caravita S. Discrepancy in the Diagnosis of Heart Failure With Preserved Ejection Fraction Between Supine Versus Upright Exercise Hemodynamic Testing. Circ Heart Fail. 2024 Nov 8:e012020. doi: 10.1161/CIRCHEARTFAILURE.124.012020. Epub ahead of print. PMID: 39513293
  5. Dzemali O, Rodriguez Cetina Biefer H, Di Eusanio M, Fabre O, Troise G, Bonaros N, Grimaldi F, Choi YH, Santarpino G, Baeza C, Pollari F, Marcheix B, Pacini D, Argano V, Baghai M, Bhabra M, Mazzaro E, Badano L, Kempfert J. Mitral valve repair with the semirigid MEMO 4D annuloplasty ring: early clinical and echocardiographic outcomes from the MANTRA study. Interdiscip Cardiovasc Thorac Surg. 2024 Dec 12:ivae208. doi: 10.1093/icvts/ivae208. Epub ahead of print. PMID: 39666948

2025

  1. Cotella JI, Blitz A, Clement A, Tomaselli M, Muraru D, Badano LP, Sauber N, Calvarons AF, Degel M, Rucki A, Blankenhagen M, Yamat M, Schreckenberg M, Addetia K, Asch FM, Mor-Avi V, Lang RM; WASE Investigators. 3D Transthoracic Echocardiography for Semiautomated Analysis of the Tricuspid Annulus: Validation and Normal Values. J Am Soc Echocardiogr. 2024 Sep 18:S0894-7317(24)00453-X. doi: 10.1016/j.echo.2024.09.007. Epub ahead of print. PMID: 39304089
  2. Kemaloğlu Öz T, Badano LP. Unlocking the Potential of Three-Dimensional Echocardiography for Diagnosing Pulmonary Valve Diseases. Balkan Med J. 2025 Jan 2;42(1):1-2. doi: 10.4274/balkanmedj.galenos.2024.2024-5-125. PMID: 39757384
  3. Clement A, Tomaselli M, Badano LP, Hadareanu DR, Radu N, Penso M, Caravita S, Baratto C, Fisicaro S, Delcea C, Rota A, Sascau R, Muraru D. Association with Outcome of the Regurgitant-Volume Adjusted Right Ventricular Ejection Fraction in Secondary Tricuspid Regurgitation. J Am Soc Echocardiogr. 2025 Jan 21:S0894-7317(25)00039-2. doi: 10.1016/j.echo.2025.01.008. Epub ahead of print. PMID: 39848504.
  4. Tomaselli M, Penso M, Badano LP, Clement A, Radu N, Heilbron F, Benzoni G, Hădăreanu DR, Springhetti P, Giorgio O, Caravita S, Baratto C, Sorropago A, Fisicaro S, Parati G, Muraru D. Right Ventricular Function and Outcomes Stratified by the Effective Regurgitant Orifice Area in Secondary Tricuspid Regurgitation. Can J Cardiol. 2025 Jan 13:S0828-282X(25)00013-3. doi: 10.1016/j.cjca.2025.01.006. Epub ahead of print. PMID: 39814179
  5. Clement A, Muraru D, Fisicaro S, Penso M, Tomaselli M, Radu N, Delcea C, Buta AS, Rella V, Sascau R, Badano LP. Utility of the Ratio Between the Size of the Right Atrium and the Right Ventricle at End-Systole to Diagnose Atrial Secondary Tricuspid Regurgitation. J Am Soc Echocardiogr. 2025 Mar;38(3):212-223. doi: 10.1016/j.echo.2024.11.012. Epub 2024 Dec 11. PMID: 39667635.
  6. Tomaselli M, Springhetti P, Benfari G, Penso M, Clement A, Pilan M, Leonardi D, Ciceri L, Buta A, Scarsini R, Calin A, Nitu C, Radu N, Muraru D, Popescu B, Ribichini F, Badano LP. A Novel Staging System of Cardiac Damage in Aortic Stenosis based on Multi-Chamber Myocardial Deformation. Eur Heart J Cardiovasc Imaging. 2025; 26(5):908-917. doi: 10.1093/ehjci/jeaf035. Epub ahead of print. PMID: 39874256
  7. Badano LP, Penso M, Tomaselli M, Kim K, Clement A, Radu N, Hong GR, Hădăreanu DR, Buta A, Delcea C, Fisicaro S, Parati G, Young Shim C, Muraru D. Advanced echocardiography and cluster analysis to identify secondary tricuspid regurgitation phenogroups at different risk. Rev Esp Cardiol (Engl Ed). 2025 Feb 21:S1885-5857(25)00057-X. English, Spanish. doi: 10.1016/j.rec.2025.02.004. Epub ahead of print. PMID: 39988031
  8. Springhetti P, Tomaselli M, Portolan L, Penso M, Pizzini J, Leonardi D, Clement A, Ciceri L, Radu N, Benzoni G, Scarsini R, Ribichini F, Muraru D, Benfari G, Badano LP. Transaortic Flow Rate and Risk-Stratification in moderate Aortic Stenosis. J Am Soc Echocardiogr. 2025 Mar 7:S0894-7317(25)00118-X. doi: 10.1016/j.echo.2025.02.017. Epub ahead of print. PMID: 40058713
  9. Ladányi Z, Lakatos BK, Clement A, Tomaselli M, Fábián A, Radu N, Turschl TK, Ferencz A, Merkely B, Surkova E, Kovács A, Muraru D, Badano LP. Mechanical adaptation of the right ventricle to secondary tricuspid regurgitation, and its association with patients' outcomes. J Am Soc Echocardiogr. 2025 Feb 22:S0894-7317(25)00105-1. doi: 10.1016/j.echo.2025.02.011. Epub ahead of print. PMID: 39993648
  10. Genovese D, Previtero M, Prete G, et al. Comparison of the Right Atrial Expansion Index with Inferior Vena Cava Assessment for Echocardiographic Estimation of the Right Atrial Pressure. J Am Soc Echocardiogr. 2025 Sep:S0894-7317(25)00522-X. DOI: 10.1016/j.echo.2025.09.005. PMID: 40967280
  11. Heitzinger G, Dreyfus J, Dannenberg V, et al. Left ventricular ejection fraction and benefit of tricuspid valve interventions - insights from the international TRIGISTRY. Eur J Heart Fail 2025 Aug. DOI: 10.1002/ejhf.3797. PMID: 40886066
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Awards

La professoressa Muraru è President-Elect della European Association of Cardiovascular Imaging.

Il centro di risonanza magnetica cardiaca ha ricevuto l'accreditamento della European Association of Cardiovascular Imaging

Il prof Badano è il coordinatore del gruppo di studio cardiopatie valvolari della Società Italiana di Cardiologia.

Il prof Badano è il coordinatore del Working Group for Patient care pathway per il PCR Tricuspid focus group

3 membri dello staff del laboratorio di ecocardiografia hanno ricevuto la certificazione di competenza della European Association of Cardiovascular Imaging.

PRINCIPALI COLLABORAZIONI A NETWORK DI RICERCA NAZIONALI E INTERNAZIONALI

TRIREGISTRY.

PCR Tricuspid Focus Group.

Gruppo di studio su cardiopatie valvolari della Società Italiana di Cardiologia.

Gruppo di studio su risonanza magnetica cardiaca della Società Italiana di Cardiologia.

World Alliance Societies of Echocardiography Normal Values Study.

European Society of Cardiology EORP EURO-ENDO registry.

Gruppo di studio AC-TIVE per la diagnosi ecocardiografica dell’amiloidosi cardiaca.