Laboratorio sperimentale ricerche Biomarcatori Danno d'Organo

Laboratori di ricerca Auxologico
Torna indietro

Sei in AUXOLOGICO

Laboratorio sperimentale ricerche Biomarcatori Danno d'Organo

Direttore: Prof. Massimiliano Corsi Romanelli

ATTIVITÀ DI RICERCA

Valutazione di biomarcatori cellulari e molecolari di malattie complesse quali dismetabolismi, patologia cardiometabolica, patologie da glicazioni.

MALATTIE E BIOMARCATORI OGGETTO DI RICERCA

  • Patologia Cardio-Renale;
  • CKD/DKD;
  • Pathways ST2/IL-33;
  • GLP-1;
  • Fibrosi Cardiaca;
  • NLRP3 pathway;
  • RAGE e sottoclassi c, e, s in patologia umana;
  • KLOTHO alpha.

RISULTATI DI PARTICOLARE IMPORTANZA RAGGIUNTI

Identificazione di nuovi biomarcatori cellulari e molecolari che intervengono nell’inflammosoma, nel lipidoma e che regolano la suscettibilità a sviluppare obesità, ed in particolare patologie cardiometaboliche.

  • 1: Malavazos AE, Dubini C, Milani V, Boveri S, Meregalli C, Bertolini C, Buscemi C, Cardani R, Renna LV, Trevisan MB, Scravaglieri V, Cuppone MT, Menicanti L, Costa E, Ambrogi F, Ruocco C, Carruba M, Iacobellis G, Nisoli E, Corsi Romanelli MM. BNT162b2 Booster Dose Elicits a Robust Antibody Response in Subjects with Abdominal Obesity and Previous SARS-CoV-2 Infection. Vaccines (Basel). 2023 Nov 30;11(12):1796. doi: 10.3390/vaccines11121796. PMID: 38140200; PMCID: PMC10747120. IF 3.4 CS 9.9.
     
  • 2: Galliera E, Massaccesi L, Suardi V, de Vecchi E, Villa F, Yi Z, Suo G, Lovati AB, Logoluso N, Corsi Romanelli MM, Pellegrini AV. sCD14-ST and Related Osteoimmunological Biomarkers: A New Diagnostic Approach to Osteomyelitis. Diagnostics (Basel). 2024 Jul 23;14(15):1588. doi: 10.3390/diagnostics14151588. PMID: 39125464; PMCID: PMC11312423. IF 3.3 CS 5.9.
     
  • 3: Galliera E, Massaccesi L, Mangiavini L, De Vecchi E, Villa F, Corsi Romanelli MM, Peretti G. Effects of COVID-19 on bone fragility: a new perspective from osteoimmunological biomarkers. Front Immunol. 2024 Nov 7;15:1493643. doi: 10.3389/fimmu.2024.1493643. PMID: 39582872; PMCID: PMC11582977. IF 5.9 CS 10.8.
     
  • 4: Buoli M, Dozio E, Caldiroli L, Armelloni S, Vianello E, Corsi Romanelli MM, Castellano G, Vettoretti S. Clinical Factors and Biomarkers Associated with Depressive Disorders in Older Patients Affected by Chronic Kidney Disease (CKD):
  • Does the Advanced Glycation End Products (AGEs)/RAGE (Receptor for AGEs) System Play Any Role? Geriatrics (Basel). 2024 Jul 30;9(4):99. doi: 10.3390/geriatrics9040099. PMID: 39195129; PMCID: PMC11353441. IF 2.1 CS 3.4.
     
  • 5: Vianello E, Ambrogi F, Kalousová M, Badalyan J, Dozio E, Tacchini L, Schmitz G, Zima T, Tsongalis GJ, Corsi-Romanelli MM. Circulating perturbation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) is associated to cardiac remodeling and NLRP3 inflammasome in cardiovascular patients with insulin resistance risk. Exp Mol Pathol. 2024 Jun;137:104895. doi: 10.1016/j.yexmp.2024.104895. Epub 2024 May 3. PMID: 38703553. IF 3.7. CS 6.6.
     
  • 6: Bianchi F, Roccabianca P, Vianello E, Gentile G, La Sala L, Bandera F, Tacchini L, Zoia R, Corsi Romanelli MM, Dozio E. Inhibition of DPP-4 Attenuates Endotoxemia-Induced NLRC4 Inflammasome and Inflammation in Visceral Adipose Tissue of Mice Fed a High-Fat Diet. Biomolecules. 2025 Feb 25;15(3):333. doi: 10.3390/biom15030333. PMID: 40149869; PMCID: PMC11940500. IF 4.8 CS 9.2.
     
  • 7: Vianello E, Beltrami AP, Aleksova A, Janjusevic M, Fluca AL, Corsi Romanelli MM, La Sala L, Dozio E. The Advanced Glycation End-Products (AGE)-Receptor for AGE System (RAGE): An Inflammatory Pathway Linking Obesity and Cardiovascular Diseases. Int J Mol Sci. 2025 Apr 14;26(8):3707. doi: 10.3390/ijms26083707. PMID: 40332316; PMCID: PMC12028226. IF 4.9 CS 9.0.
     
  • 8: Salvatici M, Sommese C, Corsi Romanelli MM, Drago L. Review of Literature and Recommended Procedures for Management of Unusual Cases of False Positive Troponin Tests. Int J Mol Sci. 2025 Jan 26;26(3):1045. doi: 10.3390/ijms26031045. PMID: 39940813; PMCID: PMC11817740. IF 4.9 CS 9.0.
     
  • 9: Galliera E, Massaccesi L, Mangiavini L, De Vecchi E, Villa F, Corsi Romanelli MM, Peretti GM. The Evaluation of New-Generation Biomarker sCD14ST Provides New Insight into COVID-19's Effect on Bone Remodeling. J Clin Med. 2025 Feb 3;14(3):979. doi: 10.3390/jcm14030979. PMID: 39941649; PMCID: PMC11818815. IF 2.9 CS 5.2.
     
  • 10: Dozio E, Tassistro E, Orlando A, Giussani M, Beba G, Patti I, Lieti G, Antolini L, Vianello E, Corsi Romanelli MM, Parati G, Genovesi S. The soluble receptor for advanced glycation end products is independently associated with systolic blood pressure values and hypertension in children. Nutr Metab Cardiovasc Dis. 2025 Jul;35(7):103862. doi: 10.1016/j.numecd.2025.103862. Epub 2025 Jan 10. PMID: 39934046. IF 3.7 CS 7.0.
     
  • 11: Vettoretti S, Caldiroli L, Molinari P, Villa A, Corsi Romanelli MM, Vianello E, Dozio E, Genovesi S. Exploring the Interplay Between Glycated Albumin, AGEs, and Inflammation in Old Patients with CKD. Metabolites. 2025 Aug 1;15(8):515. doi: 10.3390/metabo15080515. PMID: 40863134; PMCID: PMC12388635. IF 3.7 CS 6.9.
     
  • 12: Massaccesi L, Corsi Romanelli MM, Galliera E. Brain-Bone Axis in Physiological and Pathological Conditions. Int J Mol Sci. 2025 Oct 9;26(19):9822. doi: 10.3390/ijms26199822. PMID: 41097093; PMCID: PMC12525286. IF 4.9 CS 9.0.
     
  • 13: La Sala L, Carlini V, Macas-Granizo MB, Trabucchi E, Pontiroli AE, Berra C, Naselli A, D'Anzeo M, Porta A, Martin Delgado J, Vianello E, Dozio E, Corsi Romanelli MM, Drago L. The eternal struggle between titans: Fecal microbiota transplant (FMT) versus metformin in type 2 diabetes (T2D) gut dysmotility. J Adv Res. 2025 Sep 14:S2090-1232(25)00704-0. doi: 10.1016/j.jare.2025.09.021. Epub ahead of print. PMID: 40957477. IF 13.0 CS 22.
     
  • 14: Bellet MM, Curcio F, Frati L, Pariano M, Romani L, Corsi-Romanelli MM. The Gut Microbiome as a Possible Mediator in Autoimmunity and Cardiovascular Disease: Shared Pathways and Therapeutic Implications. Am J Pathol. 2025 Sep 26:S0002-9440(25)00358-X. doi: 10.1016/j.ajpath.2025.08.015. Epub ahead of print. PMID: 41016544. IF 3.6 CS 9.

PRINCIPALI COLLABORAZIONI

  • Institute of Medical Biochemistry and Laboratory Diagnostic, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12108 Prague, Czech Republic ;
  • Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami, FL, USA;
  • Unit of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy;
  • Department of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany;
  • IRCCS Policlinico San Donato, San Donato Milanese, P.za Edmondo Malan 1, Italia (RETE CARDIOVASCOLARE).

COMPONENTI DEL LABORATORIO SPERIMENTALE

  • Prof.ssa Elena DOZIO, PhD Associato di Patologia Clinica;
  • Prof.ssa  Lorenza TACCHINI, PhD Associato di Patologia Generale;
  • Prof.ssa Elena VIANELLO, PhD, Associato di Patologia Clinica;
  • Prof. Massimiliano M. CORSI ROMANELLI, MD PhD Ordinario di Patologia Clinica.