Dott.ssa Cecilia Beatrice Chighizola


Staff U.O. Immunologia, Allergologia e Reumatologia - San Luca - Auxologico San Luca

2016 – oggi
Ricercatore a Tempo Determinato (Lettera A), SSD MED/16 Reumatologia, Dipartimento di Scienze Cliniche e di Comunità, Università di Milano.

Medico convenzionato, Istituto Auxologico Italiano.

2012 - 2015
Medico Reumatologo Libero Professionista, Istituto Auxologico Italiano, sede di Meda.

Assegnista di Ricerca, Dipartimento di Scienze Cliniche e di Comunità, Università di Milano.

2010 - 2011
Clinical and Research Fellow, Rheumatology Unit, Royal Free Hospital, University College London, Londra (UK).

2006 
Laurea Magistrale in Medicina e Chirurgia (110/110 lode) presso l’Università Vita-Salute San Raffaele, Milano.

2011
Specializzazione in Reumatologia (70/70 lode) presso l’Università di Milano.

2015
Dottorato di Ricerca in Patologia e Neuropatologia Sperimentali, Università di Milano.

2016
Master Universitario di secondo livello in Ricerca Traslazionale in Reumatologia, Università di Trieste.

  • Corso di Laurea in Medicina e Chirurgia, Università di Milano, Milano (Italia);
  • Corso di Laurea in Biotecnologie Mediche, Università di Milano, Milano (Italia);
  • Corso di Laurea in Tecniche Ortopediche, Università di Milano, Milano (Italia);
  • Corso di Laurea in Medicina e Chirurgia, Royal Free Hospital, University College London, Londra (Regno Unito)​.

La dottoressa Chighizola si occupa della diagnosi e della terapia delle diverse patologie reumatologiche, quali artriti infiamatorie, miopatie, connettiviti, artrosi, osteoporosi…

In particolare, ha focalizzato il proprio interesse clinico sulle connettiviti sistemiche quali sclerosi sistemica, sindrome da anticorpi anti-fosfolipidi, lupus eritematoso sistemico, connettivite indifferenziata, connettivite mista. Si dedica anche alla gestione della gravidanza in pazienti con malattie autoimmuni sistemiche.

L’attività di ricerca della dottoressa Chighizola si è concentrata su tre argomenti:

  • Meccanismi patogenetici della sindrome da anticorpi anti-fosfolipidi
  • Meccanismi patogenetici della sclerosi sistemica
  • Gravidanza nelle malattie autoimmuni sistemiche

Articoli su rivista:

  • Chighizola CB, Raimondo MG, Meroni PL. Does APS impact women's fertility? Curr Rheumatol Rep. 201719(6):33.
  • Chighizola CB, Raimondo MG, Meroni PL. Management of thrombotic antiphospholipid syndrome. Semin Thromb Hemost. 2017 Mar 9. doi:10.1055/s-0036-1597282.
  • Chighizola CB, Ong VH, Meroni PL. The use of cyclosporine A in rheumatology: a 2016 comprehensive review. Clin Rev Allergy Immunol. 2017;52(3):401-423.
  • Chighizola CB, Pregnolato F, Raschi E, Grossi C, Gentilini D, Borghi MO, Chen P, Meroni PL. Antiphospholipid antibodies and infertility: A gene expression study in decidual stromal cells. Isr Med Assoc J. 2016;18(3-4):146-9.
  • Chighizola CB, Pregnolato F, Meroni PL, Denton CP, Ong VH. N-terminal proBrain Natriuretic Peptide as predictor of outcome in scleroderma renal crisis. Clin Exp Rheumatol 2016;34(5):122-128.
  • Chighizola CB, de Jesus GR, Branch W D. The hidden world of anti-phospholipid antibodies and female infertility: A literature appraisal. Autoimmun Rev. 2016;doi: autrev.2016.01.018. 
  • Chighizola CB, Raschi E, Banzato A, Borghi MO, Pengo V, Meroni PL. The challenges of lupus anticoagulants. Expert Rev Hematol. 2016;3:1-12.
  • Chighizola CB, Raschi E, Borghi MO, Meroni PL. Update on the pathogenesis and treatment of the antiphospholipid syndrome. Curr Opin Rheumatol. 2015;27(5):476-82.
  • Chighizola CB, Ubiali T, Meroni PL. Treatment of thrombotic antiphospholipid syndrome: The rationale of current management-an insight into future approaches. J Immunol Res. 2015;2015:951424.
  • Andreoli L, Chighizola CB, Nalli C, Gerosa M, Borghi MO, Pregnolato F, Grossi C, Zanola A, Allegri F, Norman GL, Mahler M, Meroni PL, Tincani A. Clinical characterization of antiphospholipid syndrome by detection of IgG antibodies against β2 -Glycoprotein I domain 1 and domain 4/5: Ratio of anti-domain 1 to anti-domain 4/5 as a useful new Biomarker for antiphospholipid syndrome. Arthritis Rheumatol. 2015;67(8):2196-204.
  • Chighizola CB, Andreoli L, de Jesus GR, Banzato A, Pons-Estel GJ, D Erkan on behalf of APS ACTION. The association between antiphospholipid antibodies and pregnancy morbidity, stroke, myocardial infarction, and deep vein thrombosis: a critical review of the literature. Lupus 2015;24(9):980-4. 
  • Meroni PL, Chighizola CB, Gerosa M, Trespidi L, Acaia B. Obstetric antiphospholipid syndrome: lobsters only? Or should we also look for red herrings? J Rheumatol 2015;42(2):158-60
  • Chighizola C, Gerosa M, Trespidi L, Di Giacomo A, Rossi F, Acaia B, Meroni PL. Update on the current recommendations and outcomes in pregnant women with antiphospholipid syndrome. Expert Rev Clin Immunol 2014;10(11):1505-17
  • Borghi M, Raschi E, Grossi C, Chighizola C, Meroni P. Toll-like receptor 4 and β2 glycoprotein I interaction on endothelial cells. Lupus 2014;23(12):1302-4
  • Chighizola C, Moia M, Meroni P. New oral anticoagulants in thrombotic antiphospholipid syndrome. Lupus 2014;23(12):1279-82
  • Chighizola C, de Jesus G. Antiphospholipid antibodies and infertility. Lupus 2014;23(12):1232-8
  • Meroni PL, Chighizola CB, Rovelli F, Gerosa M. Antiphospholipid syndrome in 2014: more clinical manifestations, novel pathogenic players and emerging biomarkers. Arthritis Res Ther 2014;16(2):209
  • Bertolaccini ML, Amengual O, Andreoli L, Atsumi T, Chighizola CB, Forastiero R, de Groot P, Lakos G, Lambert M, Meroni P, Ortel TL, Petri M, Rahman A, Roubey R, Sciascia S, Snyder M, Tebo AE, Tincani A, Willis R. 14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends. Autoimmun Rev 2014;13(9):917-30 
  • Raschi E, Chighizola CB, Grossi C, Ronda N, Gatti R, Meroni PL, Borghi MO. β2-glycoprotein I, lipopolysaccharide and endothelial TLR4: Three players in the two hit theory for anti-phospholipid-mediated thrombosis. J Autoimmun 2014;55:42-50 
  • de Jesus GR, Agmon-Levin N, Andrade CA, Andreoli L, Chighizola CB, Porter TF, Salmon J, Silver RM, Tincani A, Branch DW. 14th International Congress on Antiphospholipid Antibodies Task Force report on obstetric antiphospholipid syndrome. Autoimmun Rev 2014;13:795-813
  • Valcamonica E, Chighizola CB, Comi D, De Lucia O, Pisoni L, Murgo A, Salvi V, Sozzani S, Meroni PL. Levels of chemerin and interleukin 8 in the synovial fluid of patients with inflammatory arthritides and osteoarthritis. Clin Exp Rheumatol 2014;32(2):243-50
  • Moinzadeh P, Fonseca C, Hellmich M, Shah AA, Chighizola C, Denton CP, Ong VH. Association of anti-RNA polymerase III autoantibodies and cancer in scleroderma. Arthritis Res Ther 2014;16(1):R53
  • Chighizola CB, Gerosa M, Meroni PL. New tests to detect antiphospholipid antibodies: anti-domain I beta-2-glycoprotein-I antibodies. Curr Rheumatol Rep 2014;16(2):402 
  • Chighizola CB, Andreoli L, Erkan D. Reply: To PMID 23861221. Arthritis Care Res (Hoboken) 2014;66:966-7
  • Andreoli L, Chighizola CB, Banzato A, Pons-Estel GJ, de Jesus GR, Erkan D. Estimated frequency of antiphospholipid antibodies in patients with pregnancy morbidity, stroke, myocardial infarction, and deep vein thrombosis: a critical review of the literature. Arthritis Care Res (Hoboken) 2013;65(11):1869-73
  • Pregnolato F, Chighizola CB, Encabo S, Shums Z, Norman GL, Tripodi A, Chantarangkul V, Bertero T, De Micheli V, Borghi MO, Meroni PL. Anti-phosphatidylserine/prothrombin antibodies: an additional diagnostic marker for APS? Immunol Res 2013;56(2-3):432-8
  • Ronda N, Favari E, Borghi MO, Ingegnoli F, Gerosa M, Chighizola C, Zimetti F, Adorni MP, Bernini F, Meroni PL. Impaired serum cholesterol efflux capacity in rheumatoid arthritis and lupus erythematosus. Ann Rheum Dis 2013;73(3):609-15
  • Chighizola C, E Favalli, Meroni PL. Novel mechanisms of action of the biologicals in rheumatic diseases. Clinic Rev Allerg Immunol 2012;47(1):6-16
  • Meroni PL, Chighizola C. Pathophysiology of the antiphospholipid syndrome (APS). La Revue de médecine interne; 2012:SA2–A4
  • Erkan D, Lockshin MD, Andreoli L, et al. APS ACTION--AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking. Lupus 2012;21(7):695-8
  • Chighizola C, Meroni PL, Schreiber B, Coghlan G, Denton C, Ong V. Role of N-terminal pro-Brain Natriuretic Peptide in detecting clinically significant cardiac involvement in systemic sclerosis patients. Clin Exp Rheumatol 2012;30(2S71):81-85
  • Schioppo T, Artusi C, Ciavarella T, Ingegnoli F, Murgo A, Zeni S, Chighizola C, Meroni PL. N-TproBNP as Biomarker in systemic sclerosis. Clin Rev Allergy Immunol 2012;43(3):292-301
  • Chighizola C, Schioppo T, Ingegnoli F, Meroni PL. Potential Effect of Anti-Inflammatory Treatment on Reducing the Cardiovascular Risk in Rheumatoid Arthritis. Curr Vasc Pharmacol 2012;10(5):639-46
  • Chighizola C, Meroni PL. Role of environmental estrogens and autoimmunity. Autoimmunity Rev 2012;11:A493-501
  • Chighizola C, Shoenfeld Y, Meroni PL. Systemic sclerosis. Introduction. Autoimmun Rev 2011;10:239-40
  • Sabbadini MG, Ferrarini M, Stopacciaro A, Salmaggi C, Salvo F, Chighizola C. Clinical evaluation and immunohistochemical study in five patients with Erdheim-Chester 
  • Società Italiana di Reumatologia (SIR)
  • Commissione SIR YOUNG
  • Emerging EULAR Network (EMEUNET)
  • AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking (APS ACTION)

In quanto membro dell’APS ACTION, la dottoressa Chighizola collabora con i diversi centri afferenti per la realizzazione degli studi promossi da tale organizzazione internazionale.

Ha inoltre mantenuto la collaborazione con il centro di Reumatologia del Royal Free Hospital di Londra (UK), dove ha lavorato tra il 2010 ed il 2011.

2017: “Premio SIR per I migliori contributi sottomessi da Soci SIR under 40”, CORA 2017 (Bologna, Italy)

2016: “Best Poster Award”, 4th systemic sclerosis world congress (Lisbon, Portugal)

2014: Premio "Verso EULAR 2015", Congresso SIR (Rimini, Italia)

2014: "Best Poster Award", World Congress on systemic sclerosis (Roma, Italia)

2013: "Travel grant BIOLUPUS", 10th International Lupus Congress (Buenos Aires, Argentina)

2012: "Travel grant Gruppo Italiano LES", EULAR 2012 (Berlino, Germania)

2011: "APS ACTION Young Scholar Award" (Chicago, USA)